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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name VEGF siRNA
ncRNA Category siRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line human RB cell lines SO-RB50 and HXO-RB44
Methods siRNA transfection, qPCR, Western blot, ELISA
Expression pattern associated
Functional description The chemically synthesized VEGF siRNA dramatically suppressed tumor angiogenesis (CD34 immunohistochemistry) and tumor growth in the SO-RB50 subcutaneous xenograft model.
PubMed ID 17284938
Year 2007
Title VEGF-targeted RNA interference suppresses angiogenesis and tumor growth of retinoblastoma.
Drug-related ncRNA NO

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